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   <ui>1748-7161-4-S2-O10</ui>
   <ji>1748-7161</ji>
   <fm>
      <dochead>Oral presentation</dochead>
      <bibl>
         <title>
            <p>A comprehensive model of idiopathic scoliosis (IS) progression, based on the patho-biomechanics of the deforming "three joint complex"</p>
         </title>
         <aug>
            <au id="A1" ca="yes">
               <snm>Grivas</snm>
               <fnm>TB</fnm>
               <insr iid="I1"/>
               <email>grivastb@vodafone.net.gr</email>
            </au>
            <au id="A2">
               <snm>Vasiliadis</snm>
               <fnm>ES</fnm>
               <insr iid="I2"/>
            </au>
            <au id="A3">
               <snm>Triantafyllopoulos</snm>
               <fnm>G</fnm>
               <insr iid="I1"/>
            </au>
            <au id="A4">
               <snm>Kaspiris</snm>
               <fnm>A</fnm>
               <insr iid="I2"/>
            </au>
         </aug>
         <insg>
            <ins id="I1">
               <p>Department of Trauma and Orthopaedics, "Tzanio" General Hospital - NHS, Tzani and Afendouli, 18536, Piraeus, Greece</p>
            </ins>
            <ins id="I2">
               <p>Department of Trauma and Orthopaedics, "Thriasio" General Hospital - NHS, G, Gennimata Av, 19600, Magoula, Attica, Greece D. Bernardou 31 str. Brilissia, 15235 Attica, Greece, 15235, Greece</p>
            </ins>
         </insg>
         <source>Scoliosis</source>
         <supplement>
            <title>
               <p>6th International Conference on Conservative Management of Spinal Deformities</p>
            </title>
            <editor>Jean Claude deMauroy, Theodoros Grivas, Patrick Knott and David Tager</editor>
            <note>A single PDF containing all abstracts in this Supplement is available <a href="http://www.biomedcentral.com/content/files/pdf/1748-7161-4-S2-full.pdf">here</a>.</note>
         </supplement>
         <conference>
            <title>
               <p>6th International Conference on Conservative Management of Spinal Deformities</p>
            </title>
            <location>Lyon, France</location>
            <date-range>21-23 May 2009</date-range>
            <url>http://www.sosort-lyon.net/</url>
         </conference>
         <issn>1748-7161</issn>
         <pubdate>2009</pubdate>
         <volume>4</volume>
         <issue>Suppl 2</issue>
         <fpage>O10</fpage>
         <url>http://www.scoliosisjournal.com/content/4/S2/O10</url>
         <xrefbib>
            <pubid idtype="doi">10.1186/1748-7161-4-S2-O10</pubid>
         </xrefbib>
      </bibl>
      <history>
         <pub>
            <date>
               <day>14</day>
               <month>12</month>
               <year>2009</year>
            </date>
         </pub>
      </history>
      <cpyrt>
         <year>2009</year>
         <collab>Grivas et al; licensee BioMed Central Ltd.</collab>
      </cpyrt>
   </fm>
   <bdy>
      <sec>
         <st>
            <p>Introduction</p>
         </st>
         <p>It was previously postulated that the intervertebral disc wedging is a significant progressive factor for mild idiopathic scoliosis (IS) curves. The present report introduces an innovative comprehensive model of IS curve progression based on intervertebral disc diurnal variation and the subsequent patho-biomechanics of the deforming "three joint complex".</p>
      </sec>
      <sec>
         <st>
            <p>Methods and materials</p>
         </st>
         <p>Throughout the day and night, due to sustained loading and unloading, the wedged intervertebral disc space in the scoliosis patient expels fluid and reabsorbs it more on the convex side. The convex side of the disc sustains a greater amount of cyclic expansion than the concave side.</p>
      </sec>
      <sec>
         <st>
            <p>Results</p>
         </st>
         <p>Consequently, the imposed convex-wise, asymmetrically concentrated cyclical loads on the adjacent immature vertebral end plates and posterior elements of the spine lead to asymmetrical vertebral growth. More specifically the loading on the two facet-joins asymmetrically increases during the day, as the wedged disc space narrows due to expelled water and it asymmetrically decreases during the night, as the disc space swells due to reabsorbed water.</p>
      </sec>
      <sec>
         <st>
            <p>Discussion</p>
         </st>
         <p>This 24 hour period of cyclic asymmetric loading leads both to asymmetric growth of the end plates and wedging of the vertebral bodies, and to similarly asymmetric growth of the pedicles and arches posteriorly as an effect of H&#252;eter-Volkmann law. It is well described that the pedicle in the convex side is more elongated than in the concave side and the facet joint larger respectively.</p>
      </sec>
      <sec>
         <st>
            <p>Significance</p>
         </st>
         <p>The proposed model may help to explain the beneficial effects of exercises, night time bracing in idiopathic scoliosis and of fusionless surgery with staples for progressive IS <abbrgrp><abbr bid="B1">1</abbr><abbr bid="B2">2</abbr><abbr bid="B3">3</abbr></abbrgrp>.</p>
      </sec>
   </bdy>
   <bm>
      <refgrp>
         <bibl id="B1">
            <title>
               <p>A comparison of the microarchitectural bone adaptations of the concave and convex thoracic spinal facets in idiopathic scoliosis.</p>
            </title>
            <aug>
               <au>
                  <snm>Shea</snm>
                  <fnm>KG</fnm>
               </au>
               <au>
                  <snm>Ford</snm>
                  <fnm>T</fnm>
               </au>
               <au>
                  <snm>Bloebaum</snm>
                  <fnm>RD</fnm>
               </au>
               <au>
                  <snm>D'Astous</snm>
                  <fnm>J</fnm>
               </au>
               <au>
                  <snm>King</snm>
                  <fnm>H</fnm>
               </au>
            </aug>
            <source>J Bone Joint Surg Am</source>
            <pubdate>2004</pubdate>
            <volume>86-A</volume>
            <issue>5</issue>
            <fpage>1000</fpage>
            <lpage>6</lpage>
            <xrefbib>
               <pubid idtype="pmpid" link="fulltext">15118044</pubid>
            </xrefbib>
         </bibl>
         <bibl id="B2">
            <title>
               <p>Intervertebral disc biomechanics in the pathogenesis of idiopathic scoliosis.</p>
            </title>
            <aug>
               <au>
                  <snm>Grivas</snm>
                  <fnm>TB</fnm>
               </au>
               <au>
                  <snm>Vasiliadis</snm>
                  <fnm>E</fnm>
               </au>
               <au>
                  <snm>Malakasis</snm>
                  <fnm>M</fnm>
               </au>
               <au>
                  <snm>Mouzakis</snm>
                  <fnm>V</fnm>
               </au>
               <au>
                  <snm>Segos</snm>
                  <fnm>D</fnm>
               </au>
            </aug>
            <source>Stud Health Technol Inform</source>
            <pubdate>2006</pubdate>
            <volume>123</volume>
            <fpage>80</fpage>
            <lpage>3</lpage>
            <xrefbib>
               <pubid idtype="pmpid" link="fulltext">17108407</pubid>
            </xrefbib>
         </bibl>
         <bibl id="B3">
            <title>
               <p>Measurements of proteoglycan and water content distribution in human lumbar intervertebral discs</p>
            </title>
            <aug>
               <au>
                  <snm>Iatridis</snm>
                  <fnm>JC</fnm>
               </au>
               <au>
                  <snm> MacLean</snm>
                  <fnm>JJ</fnm>
               </au>
               <au>
                  <snm>O'Brien</snm>
                  <fnm>M</fnm>
               </au>
               <au>
                  <snm>Stokes</snm>
                  <fnm>IA</fnm>
               </au>
            </aug>
            <source>Spine</source>
            <pubdate>2007</pubdate>
            <volume>32</volume>
            <issue>14</issue>
            <fpage>1493</fpage>
            <lpage>7</lpage>
            <xrefbib>
               <pubidlist>
                  <pubid idtype="doi">10.1097/BRS.0b013e318067dd3f</pubid>
                  <pubid idtype="pmpid" link="fulltext">17572617</pubid>
               </pubidlist>
            </xrefbib>
         </bibl>
      </refgrp>
   </bm>
</art>
